Pilot study of trigeminal nerve stimulation (TNS) for epilepsy: a proof-of-concept trial.

نویسندگان

  • Christopher M DeGiorgio
  • Alan Shewmon
  • Diane Murray
  • Todd Whitehurst
چکیده

The safety and preliminary efficacy of trigeminal nerve stimulation (TNS) for epilepsy was evaluated in a pilot feasibility study of transcutaneous stimulation of the infraorbital and supraorbital branches of the trigeminal nerve. TNS was well tolerated. Four (57%) of seven subjects who completed >or=3 months experienced a >or=50% reduction in seizure frequency. The results of this pilot study support further investigation into the safety and efficacy of TNS for epilepsy.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Trigeminal nerve stimulation may not be effective for the treatment of refractory partial seizures.

Commentary Stimulatory devices offer a novel approach for the treatment of refractory partial seizures. Both peripheral and central stim-ulatory devices that provide either continuous or responsive stimulation have been studied. Currently the only approved device is the vagus nerve stimulator (VNS). Stimulatory devices may provide a safe and well-tolerated means of reducing seizures for patient...

متن کامل

An eight-week, open-trial, pilot feasibility study of trigeminal nerve stimulation in youth with attention-deficit/hyperactivity disorder.

BACKGROUND This study examined the potential feasibility and utility of trigeminal nerve stimulation (TNS) for attention-deficit/hyperactivity disorder (ADHD) in youth. METHODS Twenty-four participants ages 7-14 with ADHD enrolled in an 8-week open trial of TNS administered nightly during sleep, and were assessed weekly with parent- and physician-completed measures of ADHD symptoms and execut...

متن کامل

Transcutaneous vagus and trigeminal nerve stimulation for neuropsychiatric disorders: a systematic review.

UNLABELLED We reviewed trigeminal nerve stimulation (TNS) and transcutaneous vagus nerve stimulation (tVNS). All techniques have shown preliminary promising results, although the results are mixed. METHOD We performed a systematic review of the Medline and Embase databases, with no constraint to dates, through June 2013. The keywords were [(1) trigeminal nerve stimulation OR (2) cranial nerve...

متن کامل

Central mechanisms of cranial nerve stimulation for epilepsy

Stimulation of peripheral cranial nerves has been shown to exert anticonvulsant effects in animal models as well as in human patients. Specifically, stimulation of both the trigeminal and vagus nerves has been shown in multiple clinical trials to be anticonvulsant, and stimulation of these nerves at therapeutic levels does not cause pain or negatively affect brain function. However, the neurona...

متن کامل

Trigeminal Nerve Stimulation for Major Depressive Disorder: An Updated Systematic Review

Context: Trigeminal nerve stimulation (TNS) is a promising non-invasive brain stimulation intervention. The TNS has been proposed for major depressive disorder (MDD) with auspicious results. The aim of this study was to review the literature on TNS for

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Epilepsia

دوره 47 7  شماره 

صفحات  -

تاریخ انتشار 2006