Pilot study of trigeminal nerve stimulation (TNS) for epilepsy: a proof-of-concept trial.
نویسندگان
چکیده
The safety and preliminary efficacy of trigeminal nerve stimulation (TNS) for epilepsy was evaluated in a pilot feasibility study of transcutaneous stimulation of the infraorbital and supraorbital branches of the trigeminal nerve. TNS was well tolerated. Four (57%) of seven subjects who completed >or=3 months experienced a >or=50% reduction in seizure frequency. The results of this pilot study support further investigation into the safety and efficacy of TNS for epilepsy.
منابع مشابه
Trigeminal nerve stimulation may not be effective for the treatment of refractory partial seizures.
Commentary Stimulatory devices offer a novel approach for the treatment of refractory partial seizures. Both peripheral and central stim-ulatory devices that provide either continuous or responsive stimulation have been studied. Currently the only approved device is the vagus nerve stimulator (VNS). Stimulatory devices may provide a safe and well-tolerated means of reducing seizures for patient...
متن کاملAn eight-week, open-trial, pilot feasibility study of trigeminal nerve stimulation in youth with attention-deficit/hyperactivity disorder.
BACKGROUND This study examined the potential feasibility and utility of trigeminal nerve stimulation (TNS) for attention-deficit/hyperactivity disorder (ADHD) in youth. METHODS Twenty-four participants ages 7-14 with ADHD enrolled in an 8-week open trial of TNS administered nightly during sleep, and were assessed weekly with parent- and physician-completed measures of ADHD symptoms and execut...
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UNLABELLED We reviewed trigeminal nerve stimulation (TNS) and transcutaneous vagus nerve stimulation (tVNS). All techniques have shown preliminary promising results, although the results are mixed. METHOD We performed a systematic review of the Medline and Embase databases, with no constraint to dates, through June 2013. The keywords were [(1) trigeminal nerve stimulation OR (2) cranial nerve...
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Stimulation of peripheral cranial nerves has been shown to exert anticonvulsant effects in animal models as well as in human patients. Specifically, stimulation of both the trigeminal and vagus nerves has been shown in multiple clinical trials to be anticonvulsant, and stimulation of these nerves at therapeutic levels does not cause pain or negatively affect brain function. However, the neurona...
متن کاملTrigeminal Nerve Stimulation for Major Depressive Disorder: An Updated Systematic Review
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ورودعنوان ژورنال:
- Epilepsia
دوره 47 7 شماره
صفحات -
تاریخ انتشار 2006